Bhargav Patel
Assistant Professor of Pharmaceutical Sciences, Medicinal Chemistry
Phone: 618-650-5088 (Office)618-650-5060 (Lab)
Fax: 618-650-5145
E-mail: [email protected]
Education
B.Pharm., 2010, Gujarat University, India
M.S. Medicinal Chemistry, 2012, St. John’s University
Ph.D. Medicinal Chemistry, 2017, St. John’s University
Postdoctoral, 2017-2021, University of Kansas/University of Notre Dame
Biography and Research Interests
Dr. Bhargav Patel was appointed as an assistant professor in the Department of Pharmaceutical Sciences in August 2021. After earning the Bachelor of Pharmacy degree from Gujarat University, India, he moved to the U.S. to pursue M.S. in medicinal chemistry at St. John’s University, NY. There, he worked on analog synthesis for the development of HCV NS5B inhibitors and anti-MRSA compounds. Further, he continued his doctoral research in medicinal chemistry under the supervision of Dr. Tanaji Talele, working on the development of P-glycoprotein and PARP-1 inhibitors. Dr. Patel followed his pursuit in the drug discovery field and joined Dr. Brian S. J. Blagg at the University of Kansas as a postdoctoral researcher. Soon, he moved with the group to the University of Notre Dame where he worked on the development of Cruentaren A analogs. Currently, Dr. Patel’s research endeavors are focused on the discovery of anti-cancer agents as well as compounds for the treatment of neurodegenerative diseases.
Selected Publications
1) Patel, Bhargav A.; D’Amico, Terin L.; Blagg, Brian S. J. Natural Products and Other Inhibitors of F1FO ATP Synthase. Eur. J. Med. Chem. 2020, 207, 112779.
2) Patel, Bhargav A.; Abel, Biebele; Barbuti, Anna M.; Velagapudi, Uday Kiran; Chen, Zhe-Sheng; Ambudkar, Suresh V.; Talele, Tanaji T. Comprehensive synthesis of amino acid-derived thiazole peptidomimetic analogues to understand the enigmatic drug/substrate-binding site of P-glycoprotein. J. Med. Chem., 2018, 61, 834.
3) Wang, Yi-Jun; Patel, Bhargav A.; Anreddy, Nagaraju; Zhang, Yun-Kai; Zhang, Guan-Nan; Alqahtani, Saeed; Singh, Satyakam; Shukla, Suneet; Kaddoumi, Amal; Ambudkar, Suresh V.; Talele, Tanaji T.; Chen, Zhe-Sheng. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep. 2017, 7, 4210.
4) Patel, Bhargav A.; Ashby, Charles R. Jr.; Hardej, Diane; Talele, Tanaji T. The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds. Bioorg. Med. Chem. Lett. 2013, 23, 5523.
5) Patel, Bhargav A.; Krishnan, Ramalingam; Khadtare, Nikhil; Basu, Amartya; Arora, Payal; Gurukumar, K. R.; Bhatt, Aaditya; Patel, Maulik R.; Dana, Dibyendu; Kumar, Sanjai; Kaushik-Basu, Neerja; Talele, Tanaji T. Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. 2013, 21, 3262.
